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This interactive mini-workshop demonstrates experimental approaches to teaching oral infections and antimicrobial salivary peptides in undergraduate microbiology courses. Participants will engage in guided activities simulating antimicrobial assays and host–microbe interactions to explore innate immune defenses. The session emphasizes active learning, inclusive teaching strategies, and practical implementation of laboratory-inspired exercises in lecture or hybrid settings. Attendees will leave with adaptable tools to enhance student engagement, conceptual understanding, and application of microbiological principles related to oral health and infection.