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Quantitative methods, a term covering computational, mathematical and statistical approaches in biology, are a major component of modern microbiology. However, undergraduate education on these techniques is typically housed in non-biology departments and developed from a mathematics-first perspective. This separation is compounded by historical adversarial relationships between mathematicians and biologists. Prior work on teaching quantitative methods to biologists aimed to integrate biological examples within introductory mathematics courses. However, we posit that this approach is inadequate, arguing instead that to prepare biology students to integrate quantitative methods into their future careers, we must develop a biology-first approach to teaching quantitative methods. We propose a two-pronged approach: (1) bolster educators' confidence in quantitative methods and (2) develop curricula with a biology-first perspective to expose students to quantitative methods. In doing so, we hope to transform quantitative biology education and empower students to confidently integrate quantitative methods into their studies.