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Undergraduate Immunology courses are of high interest but particularly challenging for students due to the involvement of myriad cells and soluble factors involved in an immune response, as well as several unusual genetic mechanisms key to aspects of adaptive immunity. This presentation will describe three hands-on activities for teaching fundamental genetic and developmental mechanisms of the immune system: V-D-J recombination that creates B- and T- cell receptor diversity, the polygeny and polymorphism that results in individual and population diversity of MHC I antigen-presenting molecules, and how MHC molecules shape the development of a repertoire of mature, naïve T cells in an individual. The activities utilize simple craft and toy items (beads, stickers, and blocks) that are easily sourced and can be completed in small or large lecture-based courses in as little as 15 minutes each, making them adaptable for teaching in a variety of contexts.
