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Non-traditional project-based assessments can make learning more memorable and engaging because students can explore topics of interest and apply their knowledge in creative ways. This Microbrew will describe a unique assessment strategy being used in a biochemistry and molecular biology course where students work in groups to create a drug education video. Students conduct research about a drug therapeutic and explain how it works at molecular, cellular, and systemic levels to treat a specific medical condition. The video assessment format encourages creativity but also ensures students gain a deeper summative understanding of the subject matter by applying course content to their own personalized project, while also developing science communication skills. This evaluation approach has the potential to be adapted to diverse learning environments where students are exploring molecular, cell and systems processes and would be of interest for instructors who wish to embed multimedia or non-traditional assessment in their course.