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Microbiology is a core course in many STEM programs of study where student success significantly depends on their understanding of the underlying concepts of mathematics, physics, and chemistry. Yet the incoming students of microbiology often have insufficient background knowledge of these fields. Furthermore, they do not necessarily see the connections between these disciplines and Microbiology which further exacerbates the problem. To remedy this, we focused on the integrative approach to teaching undergraduate course of Microbiology that incorporated the concepts of other disciplines that were essential for the comprehensive understanding of course material. Based on the course outcomes, physics and math learning tools that we created and integrated into the course proved to be a significant factor in improving student performance in Microbiology, enhancing their learning experience, and deepening connections between the STEM fields. This microbrew will focus on the development of tools and strategies for teaching integrative course of Microbiology.