Welcome to ASMCUE in Seattle, Washington! Registered attendees are able to download the mobile app onto their phone, create a log-in, and make a personalized schedule and chat with attendees. Questions? Email [email protected]
Log in to add sessions to your schedule and sync them to your phone or calendar.
Cancer is a complex disease characterized by several hundred genetic alterations that lead to “hallmark” phenotypes. Understanding how natural selection plays a role in cancer development is challenging for undergraduate students because mutations that are advantageous at the cellular level are deleterious at the organismal level. Students must therefore reason about evolution principles across biological scales. In this microbrew, we describe a new educational board game and educational intervention designed to simulate the evolution of “hallmarks of cancer” by natural selection. We used an expanded framework for cancer genotypes and phenotypes that includes emergent, complex properties of cancer - from microbiomes to epigenetics to immune modulation. Designed for up to ten players, each cell (player) acquires mutations and hallmark phenotypes over time that influence fitness in the face of several rounds of selective agents. Its impact on student learning gains is presently underway.
